Healthy Aging with Acetyl-L-Carnitine -- Improving Cognition, Memory & Nerve Function

Acetyl-L-Carnitine is found within the inner membrane of cellular mitochondria (sometimes known as "cellular power plants," which manufacture adenosine triphosphate or "ATP," which is used as energy in the brain). 

Chemically, Acetyl-L-Carnitine is structurally-related to acetylcholine, an important brain chemical for learning and memory (acetylcholine helps brain cells communicate). Acetyl-L-carnitine is absorbed into the bloodstream more efficiently than L-carnitine and Acetyl-L-carnitine passes more effectively through cell membranes to support mitochondrial function.

L-Carnitine is used by the body to transport long chain fatty acids to the mitochondria in cells, where they are burned for energy. Since this fat burning is such a major source of muscular energy, deficiencies in L-Carnitine are manifested as low energy levels and muscular weakness.

Animal studies have also indicated that supplemental Acetyl-L-Carnitine can help maintain healthy function in lipid metabolism. 

The Infamous Readers Digest Article: Dr. Bruce Ames on "The End of Aging"

Dr. Bruce Ames, a biochemist and Professor at the University of California at Berkeley had his work profiled in Readers Digest in 2003.  Dr. Ames believes that while the production of energy in the mitochondria in your cells is highly efficient, the minor element of inefficiency -- which releases free radicals -- is the cause of aging. 

Thus, to gain the full range of benefits from Acetyl-L-Carnitine, Dr. Ames is known for pairing the powerful antioxidant and "free radicals-fighter" alpha Lipoic Acid  with Acetyl-L-Carnitine. 

Notes:

1. May cause nausea, vomiting and agitation (restlessness and motor over activity).
2. Side effects reported in people with Alzheimer’s include psychiatric disturbances, such as depression, mania, confusion and aggression, but it is not clear if they are due to acetyl-L-carnitine or the condition itself.
3. No known interactions with drugs or foods.
4. Skin rash and body odor have been reported.

Independent Laboratory Tests

Research Studies

·     Onofri M, Fulgente T, Melchionda D, et al. L-Acetylcarnitine as a new therapeutic approach for peripheral neuropathies with pain. Int J Clin Pharmacol Res 1995;15(1):9-15

·     Postiglione A, Soricelli A, Cicerano U, et al.  Effect of acute administration of L-acetyl carnitine on cerebral blood flow in patients with chronic cerebral infarct. Pharmacol Res 1993;23(3):241-6

·    Rosadini G, Marenco S, Nobili F, et al. Acute effects of acetyl-L-carnitine on regional cerebral blood flow in patients with brain ischaemia. Int J Clin Pharmacol Res 1990;(1-2):123-8