Home > All Products >

SAM-e, 200 mg, 30 Tablets - Not Available.

*Clearance - Exp. 8/2013* SAM-e supports healthy moods, joints and liver function. Enteric-coated tablets in protective, easy-to-carry, blister packs. Recommend taking with B vitamins, which support SAM-e effectiveness.

Tablet Size: 4T
Retail $39.99
Our Price $99.00

Availability: Usually Ships in 1 to 2 Business Days

Description Supplement Facts


  • Supports healthy moods.
  • Encourages healthy joints and muscle comfort.
  • Supports healthy menopause.
  • Detoxifies potentially dangerous substances.
  • Supports healthy liver function.

Product Information

SAM-e (pronounced "Sammy") is the commonly used name for S-Adenosyl-Methionine. SAM-e occurs in every living cell and takes part in several biological reactions in the human body. It is considered effective for healthy moods and joint comfort and health.

The interest in SAM-e as a support for healthy moods stems from the fact that it seems to have fewer side effects than some other mood supporters and works relatively quickly. It is considered the best clinically-documented, non-prescription healthy mood supporting compound available today. SAM-e readily crosses the blood-brain barrier in humans and even helps people who have not responded to conventional methods.

Interestingly, SAM-e consistently outperforms a placebo by a substantial margin. When matched against a placebo, SAM-e wins hands down.

SAM-e is also considered a good supplement for supporting healthy menopause as well. SAM-e is considered safe for those taking hormone replacement therapies. If not on estrogen replacement, SAM-e acts quickly to balance moods—faster, in fact, than most other approaches, and, again, with minimal or no side effects.

SAM-e also supports muscle and soft tissue health and comfort. Europe (Italy & Denmark, in particular) has been the primary source of research into the use of SAM-e and soft tissue comfort.

Despite being available (by prescription) in Europe for twenty years, it was only introduced to the U.S. in February 1999, when it became one of the top-selling dietary supplements in the United States.

SAM-e takes part in the chemical process called "methylation," which is the way the body synthesizes the chemical components of cartilage and brain chemicals, and detoxifies potentially dangerous substances. Methylation relies on the presence of nutrients that supply the building blocks of methyl groups.

Methyl groups, along with appropriate enzymes, are best known for their role in converting homocysteine, a toxic acid, into methionine, an amino acid that is beneficial to the body. As levels of SAM-e decrease, so does methylation and the body's ability to detoxify itself.

SAM-e supplies the majority of the body's methyl groups and is made from methionine, which interacts with nutrients such as vitamin B6, folic acid, vitamin B12, and choline to produce SAM-e. However, the benefits of SAM-e on metabolism can be blocked when vitamin B6, B12, and folic acid are deficient.

Thus, SAM-e and the less-than-glamorous B vitamins work synergistically to maintain joint comfort.

Under normal circumstances, the liver regenerates itself and produces new cells as old ones wear out. In cases of poor liver, portions of the liver may become hardened and inactive. Studies have shown that patients with liver challenges have abnormally low levels of SAM-e.

SAM-e, as it turns out, acts as the precursor compound for both cysteine and taurine, and a tripeptide called glutathione, which is one of the most important detoxifiers and free radical scavengers in the body. Glutathione is what gives the liver the ability to rid the body of poisons and also inhibits the inflammatory response.

Nonsteroidal anti-inflammatory drugs can relieve pain and inflammation, but may wear down cartilage. In contrast, SAM-e supports cartilage health without further destruction. SAM-e also helps maintain joint fluidity and flexibility.


  • SAM-e is unstable so it is important not to take it out of the foil blister pack until you are about to use it.
  • It's also important to be careful with the foil packs, because small nicks to the foil can allow air to penetrate the tablets and damage tablets. If unprotected, SAM-e oxidizes and loses its effectiveness.
  • Also, SAM-e pills must be "enteric coated" to be effective. This allows them to pass through the stomach and be absorbed in the intestine.
  • Despite the fact that you can purchase SAM-e over-the-counter, professional help is highly recommended for (among other things): determining dosage levels, information on the types and forms of SAM-e, and judging the severity of a mood challenges.
  • Like all mood support supplements, SAM-e may trigger mania, especially in those with bipolar disorder. People with bipolar disorder taking SAM-e should be under close medical supervision.
  • While no serious adverse reports are associated with taking SAM-e in amounts up to 1,600 mg per day over long periods of time, some mild side effects can be experienced, which usually diminish with time or resolve with lower doses.
  • SAM-e, sometimes called "sam sulfate," was discovered in 1952 in Italy.
  • A healthy body produces about 8 grams of SAM-e per day, more than half of which is used by the liver to do its job!

Average Customer Review: 4.5 of 5 Total Reviews: 8 Write a review.

  0 of 0 people found the following review helpful:
SAM-e, 200 mg, 30 Tablets - Clearance! June 28, 2013
Reviewer: Anonymous Person from Murphy, NC United States  
Got the order in record time.  Great deals on everything I ordered especially this clearance item.  I will definitely be a regular customer. Thanks Our Health Co-op!

Was this review helpful to you?

  1 of 1 people found the following review helpful:
Sam-e...better than Neuro-PS? May 1, 2013
Reviewer: Linda from FL United States  
People!! ....Save yourself some money and buy Sam-e. It works just like Neuro-PS and is a lot less expensive. I use to use Neuro-PS until I gave Sam-e a chance. Now I LOVE it. Makes my mood really good. Without it I feel depressed and am sad. Be Happy, Don't cry...Take Sam-e, then you'll see why!

Was this review helpful to you?

  0 of 0 people found the following review helpful:
SAM-e April 29, 2013
Reviewer: Marj B. from Seattle, WA United States  
Recommended by our vet for one of our Basenjis who was adopted and has always be anxious around men and strangers.  He is much more relaxed since I started him on SAM-e.  OurHealthCo-ops prices on all but especially SAM-e is amazingly low.

Was this review helpful to you?

  0 of 0 people found the following review helpful:
Necessary for bone health April 9, 2012
Reviewer: Jenoese Farmer from Houston, TX United States  
I like how this product presents.

Was this review helpful to you?

  1 of 1 people found the following review helpful:
SAM-e -- love it! March 23, 2011
Reviewer: Sharon Baez from Fort Lauderdale, FL United States  
I used to wonder what this is.  I happened to read the information about it coincident with suspecting the onset of arthritis in my shoulder.  I started taking this at 4 caps per day, 2 in the morning and 2 at night, and the results within less than a month were outstanding!  I continued at that level for a little over two months and am now down to either 2 per day or 3 per day.  I love this product!

Was this review helpful to you?

View All Customer Reviews

Browse for more products in the same category as this item:

All Products
Bones and Joints
Liver and Detox
Quick Orders
Women's Health